形容词

1. 不考虑…的;不顾…的;不受…影响的
If you say that something happens or should happen irrespective of a particular thing, you mean that it is not affected or should not be affected by that thing.

1. in spite of everything
without regard to drawbacks

e.g. he carried on regardless of the difficulties

Synonym: regardlessdisregardlessno matterdisregarding