1. 起始于（某处）
If a door, room, or path leads off a place or leads off from a place, you can go directly from that place through that door, into that room, or along that path.
2. 开始；启动；带头
If someone leads off in an activity, meeting, or conversation, they start it.
3. （在棒球比赛或其一局中）率先击球
In baseball, the player who leads off is the first player to bat for their team in a game or inning.
1. set in motion, cause to start
e.g. The U.S. started a war in the Middle East
The Iraqis began hostilities
begin a new chapter in your life
2. teach immoral behavior to
e.g. It was common practice to lead off the young ones, and teach them bad habits
Synonym: lead astray