1. 不健康的；不卫生的
Unwholesome food or drink is not healthy or good for you.

2. 讨人厌的；不自然的
If you describe someone's feelings or behaviour as unwholesome, you are critical of them because they are unpleasant or unnatural.

1. detrimental to physical or moral well-being

e.g. unwholesome food
unwholesome habits like smoking