1. （与配偶）分居的
An estranged wife or husband is no longer living with their husband or wife.

2. （因与亲朋发生争吵而）疏远的，不和的，不来往的
If you are estranged from your family or friends, you have quarrelled with them and are not communicating with them.

3. （与社团、职业等）疏离的，疏远的，脱离的
If you describe someone as estranged from something such as society or their profession, you mean that they no longer seem involved in it.

1. caused to be unloved

Synonym: alienated