1. I really loused up the whole presentation.
我把整个演示讲砸了。

2. Don't louse up this great opportunity.
不要把这次大好机会搞砸了。

3. He loused up the deal at the last minute.
他在最后一刻把这笔交易弄糟了。

A: Did you finish the report for the meeting?
A：你准备好会议报告了吗？

B: I'm afraid I loused it up by forgetting the latest data.
B：恐怕我把报告搞砸了，因为我忘了最新的数据。

1) 搞砸，弄乱

2) 弄糟

1. 搞砸；弄糟

e.g.
He loused up the whole plan.
他把整个计划都搞砸了。

verb phrase

1. To ruin, spoil, or make a mess of something.

Synonym: ruin, spoil, mess up