1. 搞砸;弄糟
If you mess something up or if you mess up, you cause something to fail or be spoiled.

2. 弄脏;弄乱
If you mess up a place or a thing, you make it untidy or dirty.

3. 干扰;搅乱;使不得安宁
If something messes someone up, it causes them to be very confused or worried, or to have psychological problems.

1. make a mess of or create disorder in

e.g. He messed up his room

Synonym: mess

2. disturb the smoothness of

e.g. ruffle the surface of the water

Synonym: ruffleruffle uprumple

3. make a mess of, destroy or ruin

e.g. I botched the dinner and we had to eat out
the pianist screwed up the difficult passage in the second movement

Synonym: botchbodgebumblefumblebotch upmuffblowflubscrew upball upspoilmuck upbunglefluffbollixbollix upbollocksbollocks upbobblemishandlelouse upfoul upfuck up